Faculty of Applied Science &amp; Engineering

Computer & Electrical Engineering

NSERC

Sustainability

Subheadline

The Sustainable Data Systems for Data Science initiative aims to align Canada’s tech investments with its vision for a carbon-neutral future

The growing global adoption of artificial intelligence technologies, including machine learning, has created a new sustainability challenge: AI systems are energy-intensive – and the more sophisticated they become, the more resources they require.

To help address the issue, a team of experts including the University of Toronto’s Hans-Arno Jacobsen and Natalie Enright Jerger – both professors in the Edward S. Rogers Sr. department of electrical and computer engineering at the Faculty of Applied Science & Engineering – are launching an initiative that aims to align Canada’s tech investments with its vision for a sustainable, carbon-neutral future.

The Sustainable Data Systems for Data Science (SDSDS) project aims to train a new generation of computer and data scientists who can combine comprehensive technical skills with sustainability awareness. The project recently received a $1.6-million Collaborative Research and Training Experience (CREATE) grant from the Natural Science and Engineering Research Council of Canada (NSERC).

“A majority of students are unaware of how sustainability informs responsible development of platforms and systems because, frankly, there just aren’t many courses or learning paths available to them in this area,” says Enright Jerger, who holds the Canada Research Chair in Computer Architecture and is director of the division of engineering science.

“Another crucial component of this project is to equip our students with knowledge transfer strategies so they can seed these ideas in the workforce. Today’s trainees becoming tomorrow’s trainers.”

The SDSDS team propose training future computer systems designers to adopt a green approach when developing data analytics platforms and systems. The approach would apply to all aspects of the life cycle of development and deployment – such as hardware infrastructure, software systems and application domains.

To advance knowledge and dialogue on the issue, SDSDS will look to hold cross-university seminars on sustainability challenges and will offer courses on sustainable data science, along with summer school programs focused on energy-efficient software and hardware platforms.

The researchers also aim to connect students with industry via internships and applied research projects, enabling them to gain exposure to current challenges and facilitate cross-pollination of knowledge between industry and academia.

“The awareness about AI’s environmental impact is growing, but there is an expertise gap on how to address this very real problem – not just after the fact, but at inception. SDSDS aims to bridge this gap and prepare for the future resource demands of AI-driven industries,” says Bettina Kemme, professor of computer science at McGill University and team lead at SDSDS, which also includes Semih Salihoğlu of the University of Waterloo, Oana Balmau of McGill University and Essam Mansour of Concordia University.

“The potential of AI and machine learning systems are seemingly limitless,” says Jacobsen, who is the Jeffrey Skoll Chair in Computer Networks and Innovation. “Yet the true genius lies in building machine learning systems founded on sustainability principles. That’s real innovation.”

Researchers develop new method for delivering RNA and drugs into cells

Christopher.Sorensen — Mon, 16 Sep 2024 15:02:15 +0000

Researchers develop new method for delivering RNA and drugs into cells

Christopher.Sorensen Mon, 09/16/2024 - 11:02

Cutline

PhD candidate Kai Slaughter, left, and University Professor Molly Shoichet are exploring how ionizable drugs can be used to co-formulate small interfering RNA (siRNA) for more effective intracellular delivery (supplied images)

Qin Dai

Topic

Institute of Biomedical Engineering

Princess Margaret Cancer Centre

Temerty Faculty of Medicine

Donnelly Centre for Cellular & Biomolecular Research

University Health Network

Subheadline

"This could be a game-changer for treating complex conditions where targeting multiple pathways is beneficial, such as cancer and viral infections"

Researchers at the University of Toronto and its hospital partners have developed a method for co-delivering therapeutic RNA and potent drugs directly into cells, potentially leading to a more effective treatment of diseases.

The research, published recently in the journal Advanced Materials, explores how ionizable drugs can be used to co-formulate small interfering RNA (siRNA) for more effective intracellular delivery.

The team – including Molly Shoichet, the study’s corresponding author and a University Professor in �山ǿ��’s department of chemical engineering and applied chemistry in the Faculty of Applied Science & Engineering – specifically targeted drug-resistant cells with the delivery of a relevant siRNA. The siRNA was discovered study co-author and collaborator David Cescon, a clinician scientist at the Princess Margaret Cancer Centre, University Health Network, and an associate professor in �山ǿ��’s Temerity Faculty of Medicine.

“We found that our co-formulation method not only potently delivered siRNA to cells but also simultaneously delivered active ionizable drugs,” said research lead author Kai Slaughter, a PhD candidate in Shoichet’s lab.

“This could be a game-changer for treating complex conditions where targeting multiple pathways is beneficial, such as cancer and viral infections.”

siRNA is a powerful tool in medicine, capable of silencing specific genes responsible for disease, but delivering these molecules into cells without degradation remains a significant challenge. While recent innovations in ionizable lipid design have led to efficiency improvements, traditional nanoparticle formulations are limited in the amount of small molecule drugs they can carry.

When therapeutic formulations are absorbed by cells, small molecule drugs and siRNA are often trapped in small compartments called endosomes, preventing them from reaching their target destination and reducing their effectiveness.

The research team discovered that combining siRNA with ionizable drugs – compounds that change their charge based on pH levels – enhances the stability and delivery efficiency of siRNA inside cells, helping both the siRNA and drug escape the endosome and more effectively reach their destination. This novel method utilizes the protective properties of lipids to safeguard siRNA during its journey through the body and ensure the release of RNA and the drug together within the target cells.

“One of the biggest hurdles in siRNA therapy has been getting these molecules to where they need to go without losing their potency,” Shoichet says.

“Our approach using ionizable drugs as carriers marks a significant step forward in overcoming this barrier, while also showing how drugs and RNA can be delivered together in the same nanoparticle formulation.”

3D-printed soil? �山ǿ�� startup expands sustainable urban farming footprint in Toronto

Christopher.Sorensen — Wed, 11 Sep 2024 15:07:18 +0000

3D-printed soil? �山ǿ�� startup expands sustainable urban farming footprint in Toronto

Christopher.Sorensen Wed, 09/11/2024 - 11:07

Cutline

Leo Hua and Adnan Sharif show off fresh basil that was grown with Lyrata’s sustainable farming system at Toronto’s Casa Loma (photo by Liz Intac)

Topic

Entrepreneurship Hatchery

Innovation & Entrepreneurship

Startups

Sustainability

�山ǿ�� Scarborough

Subheadline

With new installations at Casa Loma and �山ǿ�� Scarborough, Lyrata is supplying freshly grown produce to local caterers and restaurants

A startup co-founded by a University of Toronto graduate student has its roots in an experience that is all too common for many of us.

He kept forgetting to water his plants.

“I was working in a plant immunity biology lab, so if I didn’t water them, I’d have no plants to do experiments with,” says Adnan Sharif, who is pursuing a master’s degree in the department of chemical engineering and applied chemistry in the Faculty of Applied Science & Engineering.

He says his solution was inspired by his father.

“My dad is a mechanical engineering professor at a university in Japan, and he knows a lot about manufacturing materials with porous, three-dimensional structures,” he says. “That’s how I got the idea to make my own 3D-printed soil construct, which could retain water for a week or more.

“That way, I wouldn’t have to go into the lab and water the plants so often.”

The innovation – which Sharif came up as an undergraduate working in the lab of Keiko Yoshioka, a professor in the department of cell and systems biology in �山ǿ��’s Faculty of Arts & Science – is one of several that now underpins Lyrata, a startup that grows fresh produce for caterers and high-end restaurants across the Greater Toronto Area.

The company, which got its start in a greenhouse on �山ǿ��’s St. George campus, has recently expanded with operations at �山ǿ�� Scarborough and Casa Loma, a museum, event space and historic site in midtown Toronto.

Growing plants without soil, known as hydroponics, is a technique commonly used in greenhouses worldwide. But Sharif and his team see an opportunity to make the industry more sustainable, starting with the soil replacement that the plants grow in.

“The product that almost everyone uses today is basically the same as house insulation,” Sharif says. “It’s made from rocks that are mined in remote places and shipped hundreds of kilometres to a production facility, where they are heated to thousands of degrees in a giant furnace to make a porous, chemically inert material. This material then needs to be shipped again to where it’s needed, and when you’re finished, you throw it in the garbage.”

By contrast, Lyrata’s SmartSoil is 3D-printed using biopolymers such as polylactic acid, which is derived from corn. These materials can be locally sourced and require much lower temperatures to melt and form into porous structures.

When the growing cycle is complete, the product goes through a low-heat proprietary cleaning process and can be used again. Sharif says that SmartSoil has a total lifespan of about two years, after which it can be composted along with crop residue. Together, these changes greatly lower the carbon footprint of indoor farming.

In 2020, Sharif and his co-founders brought his idea to The Entrepreneurship Hatchery, �山ǿ�� Engineering’s startup incubator and one of several entrepreneurship hubs across �山ǿ��’s three campuses. Through the Hatchery’s Nest process, they were connected with business mentors, including alumnus Xavier Tang, a consultant and venture capitalist who still advises the company today.

Over the next few years, the team evolved, with some original members leaving and others joining. They include Leo Hua, who has been pivotal to speeding the development of 3D printable soil. The concept evolved, too, as the team realized that producing food was a better business for Lyrata than rather than selling their growth medium to other farmers.

The Hatchery team – in particular, Executive Director Joseph Orozco, Go-To-Market Lead Erika J. Murray and a team of work-study students, mentors and legal externs – helped Lyrata develop their technology and business. In 2022, the Hatchery provided $155,000 in seed funding, enabling the founders to be employed by their company and further supporting business development. The funding also enabled the company to rent greenhouse space on campus, where they began growing lettuce to provide to Spaces and Experiences at �山ǿ��.

Lyrata also developed something new: a modular unit that works exclusively with their SmartSoil and contains everything required to produce a variety of indoor crops – from lights and growth medium to irrigation systems.

“None of these technological and business developments would have taken place without the generous support of the over 50 Hatchery mentors, work-study students, and legal externs who contributed to our success,” says Sharif.

“Our current concept is what we call farming-as-a-service,” Hua adds. “The SmartGrow unit we developed is small enough to fit into a standard parking spot. Our clients sign a contract with us to place a unit on their site and we take care of everything from planting to harvesting.

“For a flat fee, they get a self-contained farm that provides a reliable quantity of their desired crop over a set period of time.”

In addition to providing a locally sourced, sustainable product, Sharif says the approach can also help mitigate fluctuations in the price of wholesale produce.

“In Canada, most of our lettuce comes from California, which has been dealing with drought and many other issues,” says Sharif. “Supply chain disruptions due to COVID-19 were also a big challenge for restaurants, which have very thin margins to begin with. At one point, the price of lettuce increased by a factor of six, so you can imagine the effect that would have.”

So far, Lyrata has produced more than 15 different types of crops, including basil, parsley and mizuna, also known as Japanese mustard greens.

Support from the �山ǿ�� Engineering community has been key to Lyrata’s success.

For example, it was a �山ǿ�� Engineering alumni connection that recently led to Lyrata launching an installation at the historic Casa Loma museum and landmark in Toronto.

“Lyrata’s competitive edge is that they provide an on-site, full service and they do not take up very much space,” says Nikol Watlikiewicz, Casa Loma’s horticulture and grounds manager. “In a small corner of our potting shed, we were able to build two grow units that provide a good yield weekly, without having to train our staff on the complicated system.

“Growing indoors gives us the stability and control that traditional agriculture does not. It’s an excellent example of how engineers can help solve the global food crisis with innovative thinking.”

In August, Lyrata launched another growing unit at �山ǿ�� Scarborough, located within the Harmony Commons Dining Hall.

The priority for the next few years is growing Lyrata’s crop offerings and client base with ongoing support from The Hatchery. The incubator has facilitated graduate student placements through Mitacs, with matching funds. It also backed a recent $167,500 project with the Ontario and Canadian governments through the Sustainable Canadian Agricultural Partnership program to further advance the yield and efficiency of the SmartSoil system.

“The fact we’ve been able to come this far in such a short time is in large part due to the help we’ve had from �山ǿ�� Engineering, and especially the Entrepreneurship Hatchery,” says Sharif.

“Whether it was getting seed funding, finding mentors, hiring work-study students or making important connections through their alumni network, we wouldn’t be here without their support.”

'Helping the people I grew up with': �山ǿ�� undergrad returns home with a passion for sustainability

Christopher.Sorensen — Thu, 05 Sep 2024 15:56:08 +0000

'Helping the people I grew up with': �山ǿ�� undergrad returns home with a passion for sustainability

Christopher.Sorensen Thu, 09/05/2024 - 11:56

Cutline

Connor Isaac, a third-year mechanical engineering student, says he hopes to bring awareness of new, sustainable technologies to the community where he grew up (photo by Tristan McGuirk)

Tristan McGuirk

Topic

Mechanical & Industrial Engineering

Sustainability

Undergraduate Students

Subheadline

Connor Isaac is embarking on a year-long work experience term with Walpole Island First Nation, where he will be focused on the community's renewable energy future

Growing up on Walpole Island First Nation, Connor Isaac experienced a creative impulse from an early age – a trait that ultimately led him to the University of Toronto where he's exploring sustainability solutions.

“I would take apart electronics, I would play with Legos, play puzzle games, different things like that – it kind of fostered this creative mindset,” he says of his childhood.

“My teacher recommended that I look into engineering, and I thought, ‘You know what? That’s not a bad idea.’”

Now a third-year mechanical engineering student in �山ǿ��’s Faculty of Applied Science & Engineering, Isaac says he is preparing to give back to the community where he got his start.

He is embarking on a 12-month role working alongside Chief and Council on Walpole Island First Nation as part of the Professional Experience Year Co-op Program (PEY Co-op). As �山ǿ�� Engineering’s flagship work-experience program, the co-op allows students to graduate with up to 20 months of meaningful work experience while earning a competitive salary and gaining professional skills in industry.

“I started working with Chief and Council last summer, sitting in their meetings and just kind of assessing projects on the island. I told them that I would be completing a PEY Co-op work term, and they said it would be great if I could come back,” Isaac says.

“This time my work is going to be more focused on Walpole Island First Nation’s renewable energy future. Since it’s a whole year, I’m hoping that it gives me a good idea of what it’s like working in industry.”

Isaac, who is Chippewa (Ojibwe) and Potawatom, and was raised between Walpole Island First Nation and the nearby town of Wallaceburg, Ont., says one of his biggest motivators for returning to Walpole Island is the chance to bring awareness of new, sustainable technologies to the community.

“I’m looking forward to helping the people living on Walpole Island First Nation understand what technology we’re using, because there’s a big disconnect,” he says. “I want to help inform the community about the various things that the Council is doing that will help them.”

Isaac’s commitment to sustainability goes beyond his PEY Co-op. He’s also involved in undergraduate research with David Sinton, a professor of mechanical and industrial engineering, and his team.

“I have been working with Professor Sinton on CO2 to ethanol research, which is a carbon capture clean technology where we capture CO2 from the air to be run through an electrolyzer. This will allow us to generate ethanol and other useful carbon-based products,” Isaac says.

He is also working alongside Tracy Galloway, an associate professor of anthropology at �山ǿ�� Mississauga, as a research assistant on the CANSTOREnergy project, a �山ǿ��-led collaboration that includes researchers from 11 Canadian universities. The team is developing clean energy technologies tailored to the needs of communities in the Yukon.

“Professor Sinton told me about the CANSTOREnergy project, and I mentioned that I have worked with my reserve during the summer, communicating similar ideas to the Chief and Council, but not so much to the community,” he says.

In the past, researchers have come into Indigenous communities to conduct studies without consulting the people affected, adds Isaac.

“We’re trying to avoid that.”

Upon graduation, Isaac hopes to pursue graduate studies.

“I am heavily considering a master’s degree, but I’m not too sure in which area. I don’t want to plan too far ahead because sometimes life gets in the way,” he says.

“My focus right now is helping the people that I grew up with and giving back to the community that raised me.”

Research team explores next-gen vaccines to guard against sexually transmitted infections

Christopher.Sorensen — Wed, 04 Sep 2024 16:07:53 +0000

Research team explores next-gen vaccines to guard against sexually transmitted infections

Christopher.Sorensen Wed, 09/04/2024 - 12:07

Cutline

Aereas Aung, an assistant professor in the Institute of Biomedical Engineering , is developing new tools to study and manipulate immune cells and their reaction to vaccines (photo by Tim Fraser)

Qin Dai

Topic

Institute of Biomedical Engineering

Connaught Fund

Vaccines

Subheadline

"This work could lay the foundation for more effective vaccines that curb the spread of STIs, particularly in marginalized communities disproportionately affected by these diseases”

A research team from the University of Toronto is creating a new generation of vaccines that aims to overcome key hurdles faced by some existing formulations.

For example, a common shortcoming of many traditional vaccines is that they can’t produce antibodies in tissues where sexually transmitted infections (STIs) often enter the body.

“Most current vaccines fail to produce sufficient antibodies within mucosal tissues, leaving a significant gap in our defense against sexually transmitted infections,” says Aereas Aung, an assistant professor at the Institute of Biomedical Engineering in the Faculty of Applied Science & Engineering who is leading the research effort.

“Our goal is to develop a novel strategy that leverages the strengths of parenteral vaccination while also targeting the mucosal immune system.”

Normally vaccines are injected parenterally, meaning it is injected into or under the skin, into the muscle or directly into the bloodstream. The vaccine then travels to lymph nodes, which are small glands that help produce antibodies. Mucosal tissues in the cervix and rectum present a unique challenge since the mucus in these areas can break down the vaccine quickly and wash it away, making it difficult to reach the lymph nodes and be effective.

Aung’s research proposes fusing a protein carrier to the disease antigens, allowing it to reach distant mucosal lymph nodes after injection.

“We aim to incorporate potent immunostimulatory components into our antigen construct, optimizing its distribution and enhancing mucosal antibody responses,” says Aung.

“If successful, this work could lay the foundation for more effective vaccines that curb the spread of STIs, particularly in marginalized communities disproportionately affected by these diseases.”

Aung’s project is one of 51 �山ǿ�� faculty members whose work is being supported by the Connaught New Researcher Awards in the most recent round – and one of eight at �山ǿ�� Engineering. The award helps early-career faculty members establish their research programs.

The other �山ǿ�� Engineering researchers whose projects are supported by the award are: 

Mohammed Basheer, department of civil and mineral engineering – Integrated hydrological-statistical method and tool for landslide susceptibility mapping in a changing climate
Daniel Franklin, Institute of Biomedical Engineering – Development of equitable pulse oximeters
Sarah Haines, department of civil and mineral engineering – Open Plenums & Indoor Environments (OPEN): Evaluating the impact of return air systems on indoor environmental quality
Mark Jeffrey, Edward S. Rogers Sr. department of electrical and computer engineering – Productively surmounting the memory wall with task parallelism
Caitlin Maikawa, Institute of Biomedical Engineering – Affinity-directed dynamic polymer materials for biomarker sensing
Mohamad Moosavi, department of chemical engineering and applied chemistry – Learning the Language of Metal-Organic Frameworks Topology
Cindy Rottmann, Institute for Studies in Transdisciplinary Engineering Education and Practice (ISTEP) – But I could be fired! How early career engineers hold the public paramount from organizationally subordinate locations

�山ǿ�� researchers integrate crucial immune cells onto heart-on-a-chip platform

Christopher.Sorensen — Fri, 23 Aug 2024 12:56:51 +0000

�山ǿ�� researchers integrate crucial immune cells onto heart-on-a-chip platform

Christopher.Sorensen Fri, 08/23/2024 - 08:56

Cutline

L-R: �山ǿ�� post-doctoral fellow Shira Landau, PhD alum Yimu Zhao and Professor Milica Radisic are three of the primary authors of a study that could lead to advancements in the creation of more stable and functional heart tissues (supplied images)

Qin Dai

Topic

Institute of Biomedical Engineering

Toronto General Hospital

Donnelly Centre for Cellular & Biomolecular Research

University Health Network

Subheadline

The immune cells, known as primitive macrophages, were found to enhance heart tissue function and vessel stability

Researchers at the University of Toronto have discovered a novel method for incorporating primitive macrophages – crucial immune cells – into heart-on-a-chip technology, in a potentially transformative step forward in drug testing and heart disease modeling.

In a study published in Cell Stem Cell, an interdisciplinary team of scientists describe how they integrated the macrophages – which were derived from human stem cells and resemble those found in the early stages of heart development – onto the platforms. These macrophages are known to have remarkable abilities in promoting vascularization and enhancing tissue stability.

Corresponding author Milica Radisic, a senior scientist in the University Health Network's Toronto General Hospital Research Institute and professor in the Institute of Biomedical Engineering at �山ǿ��’s Faculty of Applied Science & Engineering, says the approach promises to enhance the functionality and stability of engineered heart tissues.

“We demonstrated here that stable vascularization of a heart tissue in vitro requires contributions from immune cells, specifically macrophages. We followed a biomimetic approach, re-establishing the key constituents of a cardiac niche,” says Radisic, who holds a Canada Research Chair in Functional Cardiovascular Tissue Engineering

“By combining cardiomyocytes, stromal cells, endothelial cells and macrophages, we enabled appropriate cell-to-cell crosstalk such as in the native heart muscle.”

Professor Milica Radisic's research team have worked on developing a miniaturized version of cardiac tissue on heart-on-a-chip platforms for a decade (photo by Nick Iwanyshyn)

A major challenge in creating bioengineered heart tissue is achieving a stable and functional network of blood vessels. Traditional methods have struggled to maintain these vascular networks over extended periods, limiting their effectiveness for long-term studies and applications.

In their study, researchers demonstrated that the primitive macrophages could create stable, perfusable microvascular networks within the cardiac tissue, a feat that had previously been difficult to achieve.

Furthermore, the macrophages helped reduce tissue damage by mitigating cytotoxic effects, thereby improving the overall health and functionality of the engineered tissues.

“The inclusion of primitive macrophages significantly improved the function of cardiac tissues, making them more stable and effective for longer periods,” says Shira Landau, a post-doctoral fellow in Radisic’s lab and one of the study’s lead authors.

The breakthrough has far-reaching implications for the field of cardiac research. By enabling the creation of more stable and functional heart tissues, researchers can better study heart diseases and test new drugs in a controlled environment.

Researchers say this technology could lead to more accurate disease models and more effective treatments for heart conditions.

Healthy aging in place: New pilot program to provide high-tech cognitive, physical enrichment for seniors

rahul.kalvapalle — Thu, 22 Aug 2024 13:32:02 +0000

Healthy aging in place: New pilot program to provide high-tech cognitive, physical enrichment for seniors

rahul.kalvapalle Thu, 08/22/2024 - 09:32

Cutline

2RaceWithMe, a tool developed by Professor Mark Chignell from the department of mechanical and industrial engineering in �山ǿ��'s Faculty of Applied Science & Engineering, combines physical and cognitive engagement by requiring users to pedal to be able to watch scenic videos (photo by Justin Greaves/Centivizer)

Safa Jinje

Topic

department of mechanical and industrial engineering

Institutional Strategic Initiatives

Connaught Fund

Subheadline

The initiative, supported by a Connaught Community Partnership Research Program award, explores the use of interactive tools to promote active lifestyles among older adults

Older adults living in a Toronto co-operative apartment building will soon have access to high-tech activity spaces designed to promote cognitive, physical and social enrichment, thanks to a new pilot project led by the University of Toronto’s Mark Chignell.

The activity spaces aim to promote healthy aging for older adults who are aging in place – meaning they have the social and health supports to live safely and independently. They will be located in the communal area of a City Park co-op building that is considered a naturally occurring retirement community, where more than 30 per cent of occupants are over the age of 65.

The initiative was launched by Chignell, a professor in the department of mechanical and industrial engineering in �山ǿ��’s Faculty of Applied Science & Engineering, in collaboration with HelpAge Canada, a non-profit that supports community-based services for seniors, and AGE-WELL, a research network and �山ǿ�� institutional strategic initiative.

It’s one of nine projects to be supported by 2024-25 Community Partnership Research Program awards, given by �山ǿ��’s Connaught Fund with the aim of accelerating research carried out in collaboration with community partners and driven by their needs and priorities.

“My work is motivated by the fact that physical and cognitive health can decline very quickly for older adults,” says Chignell.

“We know the physical body and brain work together, and that physical exercise is important for cognitive status and preventing dementia. So being able to promote more active lifestyles for people who are still living independently in the community can have an immense benefit for our society.”

The activity spaces will feature products from Centivizer, a �山ǿ�� startup spun off from Chignell’s research, that specializes in creating interactive activities, games and cognitive assessment tools to support healthy aging.

These include 2RaceWithMe, a device that promotes both physical and cognitive engagement by having users pedal while watching scenic videos that only play when the pedals are in motion.

Centivizer has also developed a suite of whack-a-mole-style games for cognitive assessment that Chignell hopes can be used to promote cognitive safety in clinical practice.

A two-time recipient of Connaught Innovation Awards, Chignell says he feels honoured to now receive support from the Connaught Fund's Community Partnership Research Program.

“The Connaught is a great validation as I start this project in naturally occurring retirement communities,” says Chignell. “I am also continuing to work with retirement homes and long-term care centres, including a new collaboration with a long-term care home in Tokyo, Japan.

“I’m hoping that this project will demonstrate the value of using our products in the community to help older people retain their physical and cognitive abilities for longer.”

�山ǿ�� startup Honeybee acquired by global clinical trials firm Leapcure

rahul.kalvapalle — Fri, 16 Aug 2024 14:55:48 +0000

�山ǿ�� startup Honeybee acquired by global clinical trials firm Leapcure

rahul.kalvapalle Fri, 08/16/2024 - 10:55

Cutline

(photo courtesy of Leapcure)

Rahul Kalvapalle

Topic

Temerty Faculty of Medicine

�山ǿ�� Entrepreneurship

Innovation & Entrepreneurship

Health Innovation Hub

Impact Centre

ONRamp

Startups

Subheadline

Co-founded by Catherine Chan and Weiwei Li, Honeybee Trials' platform helps clinical trial recruiters find, screen and manage patients for their research

Honeybee Trials, a University of Toronto startup that connects research teams with patients and study participants, has been acquired by global clinical trials company Leapcure in a deal that is poised to drive more inclusive and affordable trials that’s ultimately applicable to a broader population.

Co-founded by �山ǿ�� alumni Catherine Chan and Weiwei Li, Honeybee built a web and mobile platform to help clinical trial teams attract, screen, recruit and manage study participants. Since its founding in 2019, the startup has connected over 30,000 patients and participants to more than 1,000 clinical trials across North America.

Leapcure, headquartered in California, offers an array of solutions that combines people-backed services with data-driven technologies to fill clinical trials for global sponsors and CROs, but can now expand affordable patient recruitment to institutional sites, private sites and biotech firms. Moreover, their work alongside patients and advocacy groups has significantly helped to reach underrepresented communities – a focus that will receive a boost following the purchase of Honeybee.

Chan, who earned a master’s degree in the Temerty Faculty of Medicine’s department of nutritional sciences, says the deal grew out of a desire to partner strategically with a larger company that could provide access to broader sectors within the clinical research world.

Catherine Chan (L) and Weiwei Li (supplied image)

“At Honeybee, we offered competitive pricing for academic and hospital sites, local CROs [contract research organizations] and biotech firms,” Chan says. “With this partnership, we’re able to provide services across all of the different types of trial scopes and sizes.”

She adds that both Honeybee and Leapcure have placed a strong focus on diversity, equity, inclusion and accessibility by helping researchers attract study participants of different ethnicities, ages, genders and sexual orientations – helping make clinical trials more equitable and reflective of the wider population.

“It’s important to us that there's a mission and vision alignment between the companies... it couldn’t be a better fit,” Chan said.

The asset purchase deal for an undisclosed amount, which was announced in an Aug. 13 press release, will see Chan transition from CEO of Honeybee to senior director of product at Leapcure.

“We’re excited to join forces with Catherine and Honeybee. They’ve been really focused on the newest recruitment technologies that are most impactful for both patients and research,” said Leapcure CEO Zachary Gobst. “A big reason that things came together was our alignment on impact first. It’s a credit to how they’ve been approaching their business the right way from the beginning."

Honeybee evolved out of the frustrations that Chan faced in recruiting study participants for her master’s thesis. Motivated to explore solutions, Chan created a prototype that would help match participants with trials; she then enrolled in a one-week accelerator program in the Impact Centre (now the Centre for Entrepreneurship) in the Faculty of Arts & Science.

She soon teamed up with Li, who earned his bachelor’s and master’s of applied science degrees from the Faculty of Applied Science & Engineering, to co-found Honeybee. The startup later joined the Health Innovation Hub (H2i) accelerator and operated out of office space in �山ǿ�� Entrepreneurship’s ONRamp facility prior to the COVID-19 pandemic.

With COVID-19 measures encouraging the adoption of digital tools by clinical research teams, Honeybee found itself well-placed to play an important role. “The pandemic provided an opportunity for many tech companies to scale as the market became more open-minded and ready to adopt technologies to help connect them day-to-day," Chan says. "We saw a rapid adoption of Honeybee’s technology during this time where people moved away from traditional recruitment and patient communications to the current age.

“Although digital adoption across other industries has grown quite rapidly, healthcare has lagged behind, rightfully so and for many reasons, but we’re glad the transformation is happening. Just five years ago, clinical trial coordinators were still using paper handouts to recruit on the street and paper calendars to schedule patients.

“The pandemic expedited researchers being able to meet people where they are.”

Chan says the acquisition by Leapcure will enable the rollout of tiered services ranging from low-cost, self-serve tiers – targeting research teams with more modest budgets – to higher levels of service that include dedicated management.

“I’m really excited about the solutions we now have to offer together as well as the next steps in how we’re going to disrupt clinical trials.”

Professor Paul Santerre, co-founder and director of H2i, hailed Chan as "a model outcome" of the accelerator's mission to empower innovators in translating their ideas into products and companies that tackle important problems.

“Catherine and her team’s achievements are transformative in terms of democratizing the recruitment of patients for clinical study cohorts," said Santerre, the Baxter Chair for Health Technology and Commercialization at the University Health Network and professor in the Faculty of Dentistry and Institute of Biomedical Engineering who is cross-appointed to the department of chemical engineering and applied chemistry.

"She has much to still teach us about the power of digital tools and their ethical use to achieve impact in clinical research trials – and this acquisition will accelerate that outcome."

�山ǿ�� team takes top spot in self-driving car challenge for 6th time in 7 years

Christopher.Sorensen — Wed, 07 Aug 2024 17:42:55 +0000

�山ǿ�� team takes top spot in self-driving car challenge for 6th time in 7 years

Christopher.Sorensen Wed, 08/07/2024 - 13:42

Cutline

As part of the competition, the �山ǿ�� team’s autonomous vehicle had to react to obstacles such as a fake deer moving across the road (photo courtesy of aUToronto)

Safa Jinje

Topic

Alumni

Artificial Intelligence

Graduate Students

Self-Driving Cars

Undergraduate Students

UTIAS

Subheadline

"Each time we saw an obstacle – a stop sign, a red light, the railroad bar coming down – and the car reacted by stopping and then continuing, we let out a big cheer or a sigh of relief"

A team from the University of Toronto has placed first for sixth time in seven years in a North American self-driving car competition.

After finishing in second place last year, the aUToronto team returned to the top spot at the 2024 SAE AutoDrive Challenge II, which was held in June at the Mcity Test Facility in Ann Arbor, Mich.

The aUToronto team competed against nine other teams from across Canada and the United States.

“Through the AutoDrive Challenge, we are preparing the next generation of engineers to head into the industry, to keep pushing towards the challenging goal of reaching Level 4 autonomous driving,” says Tim Barfoot, a professor at the �山ǿ�� Institute for Aerospace Studies (UTIAS) in the Faculty of Applied Science & Engineering and one of the team’s academic advisers.

“The team did another excellent job this year.”

The team approached the competition by going back to first principles to ensure they had a reliable and robust system, says Kelvin Cui, a �山ǿ�� Engineering alumnus and the team’s principal.

He joined aUToronto last fall after five years with the University of Toronto Formula Racing team, where he founded the “driverless” division.

“We looked at what was going to get us the most points at competition and made sure that we were not overbuilding our system and adding too much complexity,” he says.

This meant pushing for additional testing time at UTIAS and achieving more than 900 kilometres of system testing prior to the competition.

The team placed first out of 10 teams from institutions across the United States and Canada (photo courtesy of aUToronto)

A partnership with the AutoDrive team from Queen’s University was instrumental to aUToronto’s preparation. The aUToronto team drove Artemis, their autonomous vehicle, to Kingston, Ont. to assess the system at Queen’s testing facility, which features intersections and electronic streetlights.

“We added radar to our vehicle as a new sensor, so we needed to be aware of all the sensor failure modes,” says third-year Engineering Science student Robert Ren.

“A lot of our testing time went into making sure that including radar didn’t break anything else in our system, and that it could handle any sensor failure cases.”

Including radar sensors in the vehicle’s perception system allowed it to measure the motion of objects directly, which is not possible with light detection and ranging (LiDAR) sensors. 

“Radar can help with adverse weather object detections,” adds Ren. “So, if the vehicle is operating under heavy rain or fog, the LiDAR is going to be limited, but the radio waves from radar can help the vehicle see what objects are in front and what objects are moving. This enables it to make good decisions when driving in uncertain scenarios.” 

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In an event where both LiDAR and radar sensors fail, the aUToronto system can still rely on visual cameras to perform object tracking. This made the team’s object tracker much more robust compared to last year when the team experienced sensor failure during a dynamic event.

Brian Cheong, a �山ǿ�� Engineering master’s student who has been a member of aUToronto since 2021, acted as technical director of the autonomy team this year – part of a new leadership structure introduced by Cui.  

“In the past, it was a lot of work for our team’s principal to keep track of all the systems,” Cheong says. “So instead of having to work directly with all 15 sub teams, Kelvin created groups of sub teams that we called stacks, and each stack had a director.”

The restructuring and technical innovations paid off, with aUToronto completing its first clean sweep in the AutoDrive Challenge II, placing first in all static and dynamic events, including the concept design presentation and intersection challenge.

“The intersection challenge was a big highlight for us,” says Cheong. “Kelvin and Robert were in the car, and I was on the sidelines watching with the rest of the team. Each time we saw an obstacle – a stop sign, a red light, the railroad bar coming down – and the car reacted by stopping and then continuing, we let out a big cheer or a sigh of relief.

“And then we were all silent as the car approached the final obstacle, which was a deer. We watched as Artemis slowed down to a stop and the deer moved by. Then we screamed and cheered, and we could hear cheering from inside the car.”

“Our success is entirely a team effort,” adds Cui. “It was not smooth sailing before the competition. The only reason we won is because everybody put in so much effort to test our vehicle every day.

“That’s how we were able to get this reliable system across the line.” 

What makes a chess move brilliant? Researchers use AI to find out

Christopher.Sorensen — Wed, 07 Aug 2024 17:25:51 +0000

What makes a chess move brilliant? Researchers use AI to find out

Christopher.Sorensen Wed, 08/07/2024 - 13:25

Cutline

�山ǿ�� Engineering researchers Kamron Zaidi, left, and Michael Guerzhoy, right, use game trees and deep neural networks to enable chess engines to recognize brilliant moves (photo by Safa Jinje)

Safa Jinje

Topic

Alumni

Artificial Intelligence

Mechanical & Industrial Engineering